AI discovery reveals DNA isn’t locked away in cells after all
In order to fit in a cell and remain organized, DNA is carefully wrapped around spool-like protein clusters called nucleosomes.
For decades, the prevailing view held that DNA is coiled so tightly around a nucleosome that it’s basically locked away and the cell can’t access it.
This is why researchers often study chromatin—which is all of a cell’s DNA packaged using nucleosomes—to get a sense of what genes a cell is using.
The same patterns appeared in human stem cells being coaxed into liver-like cells, and in liver cells taken directly from mice.
Ramani envisions using IDLI to map how nucleosome states shift across different tissues during aging.
1 час назад @ gladstone.org
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